克罗米酚对男性高促性腺素性功能减退症有效

费城（里德社健康版）1年末四日华盛顿邮报：据登载在12年末撰写的《生育与不育》杂志的一项通报反驳克罗米衍生物对部分偏高促性腺素性机能减退的未幼小患儿有利。来自考文垂新罕布什尔大学的该通报的第一所作Scott J. Whitten指导教授在给与里德通讯社谈话时说道：“原发性或能避免HH患儿在给与侵害性更多和更较贵的治疗（例如注射促性腺激素类）当年进行4个年末的克罗米衍生物除此以外治疗是有利的。”Whitten指导教授和同事科学研究了克罗米衍生物对10名HH未幼小患儿（HH是导致未幼小不育的常见因素）有否有效。通报指克罗米衍生物治疗1年后，4名卡尔曼(田氏)综合征患儿中只有一名患儿的体外酸度增高而全垂体机能减退症患儿的体外缺乏患者均没有得不到改善。比如说道，该通报反驳3名幼小病症的原发性HH未幼小患儿经过3个年末克罗米衍生物的治疗体外酸度有了明显增高。目当年为止该组患儿才有两名以后了生育能力。Whitten指导教授说道：“除非对克罗米衍生物治疗没有反应，我们不会因为阿司匹林停止对患儿使用该抗生素。”再次所作总结说道：“因为先决条件有限，对HH患儿促性腺激素类抗生素和克罗米衍生物的随机科学研究难以进行，然而利用多系列的严格选择标准对患儿进行分级可能为了让进一步验证克罗米衍生物以后未幼小偏高生育能力的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

撰写人：红色幻想

撰写人： 张靖